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Improved plan quality in multicriteria radiation therapy optimization by projections onto the Pareto surface

机译:通过投影到帕累托表面上,在多标准放射治疗优化中提高了计划质量

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摘要

We consider an approach to multicriteria radiation therapy optimization where the clinical treatment plan is selected from a representationof the set of Pareto optimal treatment plans in the form of a discrete setof plans and their combinations. The approximate nature of this representation implies that a selected plan in general has an approximationerror with respect to Pareto optimality. To assess and, if necessary, improve the quality of such plans, a technique is suggested that eliminatesthe approximation error of a given treatment plan by a projection ontothe Pareto surface. A more elaborate form of projection is also suggested that requires the projected solution to be not only as good asthe input plan in terms of objective function values, but also equallygood or better with respect to the three-dimensional dose distribution.The versatility of the suggested technique is demonstrated by application to planning for step-and-shoot and sliding window delivery ofintensity-modulated radiation therapy, and planning for spot-scanneddelivery of intensity-modulated proton therapy. Our numerical resultsshow that the proposed projections generally lead to improved sparingof organs at risk and a higher degree of dose conformity compared towhen projections are not performed.
机译:我们考虑一种多标准放射治疗优化的方法,其中以离散的一组计划及其组合的形式从一组Pareto最佳治疗计划的表示中选择临床治疗计划。这种表示的近似性质意味着,所选计划通常相对于帕累托最优性具有近似误差。为了评估并在必要时改善此类计划的质量,建议采用一种技术,该技术通过投影到帕累托表面上来消除给定治疗计划的近似误差。还提出了一种更精细的投影形式,要求投影的解决方案不仅在目标函数值方面与输入计划一样好,而且在三维剂量分布方面也同样好或更好。该技术在规划强度调制的放射治疗的步进和滑动窗口传递以及规划强度调制的质子治疗的点扫描传递中得到了证明。我们的数值结果表明,与未进行预测时相比,所提出的预测通常可以改善处于风险中的器官的稀疏性,并具有更高的剂量顺应性。

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